Pågående forskningsprojekt

Kliniskt inriktad forskning

 CORE 1

• Longitudinal studies of subjects with MCI (A Nordberg, L Minthon, A Wallin)
• Familial dementia as a model for sporadic dementia (A Nordberg)
• Development of a prospective database (M E-Jönhagen, L Minthon, A Wallin)
  

CORE 2

• Interaction of genetic and non-genetic risk factors for dementing disorders (L Fratiglioni, I Skoog)
• Exploring potential susceptibility genes for AD in the general population (L Fratiglioni, D Gustafson)
• Adiposity hormones in dementia (D Gustafson)
• Harmonisation epidemiology – clinical studies (L Fratiglioni, I Skoog)

CORE 3

• Pre-clinical detection of dementia

• A looking-glass into the brain of AD in the general population

Omvårdnadsforskning och forskning med en teknologisk inriktning

CORE 4

• The consequences and possibilities of everyday technology in persons with dementia living at home (L Nygård)
• IT based assistive technology for cognitive support (L Borell)

CORE 5

• A ward atmosphere of healing; studies of ward atmospheres (PO Sandman)
• Strain in nursing care of persons with dementia – the development of an assessment scale
  (AK Edberg)
• Transformation of the physical and psychosocial environment (H Wijk)

CORE 6

• Evaluation of emotional and cognitive impairment using VR technique in combination with MRI 
  (K Bodin)
• Dementia management supportive system - DMSS (G Bucht)

CORE 7

• Diagnostic process and cognitive tests of dementia in Primary health care (J Marcusson)
• Economic evaluation of treatments for AD (A Wimo)
• Cost of brain disorders in Europe (A Wimo)
• Development of simulation models for neurodegenerative disorders (A Wimo)
• Willingness to pay for dementia care – a methodological and explorative study (A Wimo)
• Functional capacity and costs of care (A Wimo)

Basalt inriktad forskning

CORE 8

• Modeling Parkinson’s disease - The Mitopark mouse and its implications; Modeling alcohol dehydrogenase risk factors,  OEC and DA cell grafting in the 60HDA model (L Olson)
• A role for the NOGO receptor (L Olson)
• Modeling Ageing (NG Larsson)
• Neuroplaque formation and reversion – a transgenic approach using BACE-deficient mice
  (U Lendahl)
• Molecular studies of the g-secretase complex using an in vitro system – focus on PSEN (H Karlström)
• Cytokines, microglia and neurodegeneration; Role of IL-1 system in the brain, Studies on human microglia as test systems for candidate drugs in neurodegenerative disorders such as AD (M Schultzberg)

• Identifying mechanisms for the association of the APOE polymorphism with neurodegenerative diseases (A Cedazo-Minguez)
• Role of a new molecule in brain, TRX80 (A Cedazo-Minguez)
• Transgenic Rat models of AD (E Benedikz)

CORE 9

• Familial dementia as a model for sporadic dementia (C Graff)
• Exploring potential susceptibility genes for AD in the general population (C Graff)
• Genetic association studies in AD (C Graff)
• CYP7B1 promoter polymorphism may influence the risk of AD (C Graff / S Meaney)
• Genetic variations in normal cognition and ageing (E Eriksson)
• Genetics of: Parkinsons´ Disease (H Nissbrandt, L Olson), ALS (PM Andersen), ALS and Frontotemporal dementia (C Graff / PM Andersen), MS (J Hillert)
• Characterization of novel markers of microangiopathy in dementia disorders (N Bogdanovic)

CORE 10

• Development of multiparameter CSF biomarkers for neurodegenerative disorders: the candidate biomarker and proteomics approach (K Blennow)
• Swedish multicenter ADNI-CSF study (K Blennow)
• Studies on cholesterol 24S-hydroxylase (CYP46) and its product 24S-hydroxycholesterol
  (I Björkhem)
• A new polymorphism in the HMG-CoA Reductase (HMGCR) promoter and its relationship
  to AD (I Björkhem)

Forskning med kombinerad basal/klinisk inriktning

CORE 11

• Treatment of AD transgenic Mmice with donepezil; an MRS study (LO Wahlund)
• Studies of amyloid depositons and patological processes in AD and MCI – MRI-guided PET measurements and in vitro autoradiography. Pre-studies aiming for multi-tracer molecular imaging application to improve sensitivity (B Långström)
• Development of a community based brain imaging database (LO Wahlund)

CORE 13

• Decision competence, dementia and ethics (E Sundström, M E-Jönhagen)